Treatment-Resistant Depression: A Scientist’s Discovery May Offer Hope

Dr. Jacob McCauley (right) with Miller School faculty at the genetic biorespository

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Dr. Kirill Martemyanov speaks with Dean Henri Ford about a new class of biologic therapies with rapid, lasting antidepressant effects.

What if blocking a particular brain receptor could help combat treatment-resistant depression?

On the latest episode of Inside U Miami Medicine, Henri Ford, M.D., M.H.A., dean and chief academic officer at the University of Miami Miller School of Medicine, sits down with Kirill Martemyanov, Ph.D., chair of the Department of Physiology and Biophysics at the Miller School, for a conversation about the frontiers of neuroscience, fueled by basic science research.

Dr. Martemyanov’s work focuses on advancing understanding of the brain’s molecular machinery. Recently, he and his team discovered a previously unrecognized receptor that may hold the key to treating major depressive disorder, including the treatment-resistant cases that leave so many patients without relief.

The findings, recently published in Nature Communications, point toward a bold new approach to treating these disorders, one that may lead to entirely new class of therapies called “nanobodies.”

The results are striking and the implications go far beyond depression.

Tune in to hear Dr. Martemyanov share the science, the journey to the discovery and what this could mean for the future of mental health treatment.

Listen to the full conversation on Apple, Spotify or wherever you listen to podcasts

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Tags: academic medicine, Dean Henri Ford, Department of Physiology & Biophysics, depression, Dr. Henri Ford, Dr. Kirill Martemyanov, Inside U Miami Medicine podcast, neuroscience, Newsroom